Reply to Fiscella: The phases of biomedical research should be studied to optimize health outcomes.

Distinguishing phases of biomedical research is critical to improving health outcomes.

Bowen and Casadevall (1) offer data suggesting that research inputs have not been associated with comparable increases in health outcomes over the past five decades. However, their analysis treats biomedical research the same, regardless of whether the research focuses on early phases, (i.e., basic discovery) or late phases, (i.e., comparative effectiveness and implementation and dissemination ...

How to reply to referees' comments when submitting manuscripts for publication

Background: The publication of articles in peer-reviewed scientific journals is a fairly complex and stepwise process that involves responding to referees’ comments. Little guidance is available in the biomedical literature on how to deal with such comments. Objective: The objective of this article is to provide guidance to notice writers on dealing with peer review comments in a way that maxim...

Radically Questioning the Principle of the Least Restrictive Alternative: A Reply to Nir Eyal; Comment on “Nudging by Shaming, Shaming by Nudging”

In his insightful editorial, Nir Eyal explores the connections between nudging and shaming. One upshot of his argument is that we should question the principle of the least restrictive alternative in public health and health policy. In this commentary, I maintain that Eyal’s argument undermines only a rather implausible version of the principle of the least restrictive alternative and I sketch ...

Comment to the Letter to the Editor: Subjective Symptoms Related to GSM Radiation from Mobile Phone Base Stations: a cross-sectional study In reply to the comments by Seyed Mohammad Javad Mortazavi

Investigation of Phasic Process of Biogas Yield by Measuring pH, ORP and Electrical Power Changes

Background & Aims of the Study: Studying the phasic process of the biogas yieldis required to optimize the design and operations; it also helps to lower energy production costs by decreasing the capital investment and operational costs. Here we determine the biogas process by measuring pH, ORP, electrical power and make compatibility to the biogas production trend. Materi...